Abstract
If biogenic amines are involved in the pathophysiology of Huntington's chorea, abnormalities might be detectable in blood platelets, which share many of the characteristics of amine-containing cells in the brain. The uptake of dopamine and 5-hydroxytryptamine by platelet-rich plasma from eight patients with Huntington's chorea was significantly greater than in controls, and plasma-adrenaline levels were significantly lower in the patients. If it could be shown that platelet abnormalities are present before symptoms appear, these observations might form the basis for a screening test for relatives of patients with Huntington's chorea.
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