Abstract
Pain is either very useful or very dangerous indicator for the health of human beings. Pain perception depends on the intensity and duration of noxious stimulation (Melzack and Wall, 1965), pain threshold as well as some personality factors. Therefore, pain perception = 1/pain threshold. If the pain threshold is higher then pain perception will be lower and pain stimuli ought to be raised and vice versa. A physiological function serotonin (5-hydroxytryptamine — 5-HT) is related to the increase of pain threshold (Witkop, 1991), and according to it persons with normal or increased levels of 5-HT in the central nervous system (CNS) have an optimal state decreasing pain perception (normal hypalgesia). A descending serotoninergic system, located mainly in the midline raphe of the brainstem participate in modulation pain impulses in the dorsal horns of the spinal cord (Brain, 1985; Angevine and Cotman, 1981). In the brain stem there is an endogenous analgesia system. Hyperpathia unpleasant character of pain could be found in thalamic lesions. Somatosensory and association cortex take a part in receiving pain impulses and its modulation.
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