Abstract
In vitro degradation of TRH by human plasma has been demonstrated in adults. This study concerns plasma TRH-DA during the neonatal period.(H3)TRH is incubated in 50ul of plasma, extracted and intact (H3)TRH quantitated by high pressure liquid chromatography after one hour incubation period.(H3)TRH after 0 minute incubation is the reference value and results are expressed in % TRH remaining after one hour.Paired mother and newborn (arterial cord plasma) n=7 and neonates from day 1 to 5 (n=5 each day) are studied.Maternal values TRH-DA are not significantly different from adult euthyroid control (37.5±5). Plasma of neonate have a very low TRH-DA.Activity appears at day 3 and reachs maternal values at day 5. The known increase of plasma T3 level in newborn occurs 2 days before appearance of any degrading activity.In conclusion - Plasma of newborns have no TRH-DA until day 3. This metabolic immaturity may play a role in the neonatal thyroid hyperactivity. T3 induction of this enzymatic process demonstrated in rats as to be considered in human.
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