Abstract
Peripheral plasma concentrations of progesterone, 11-deoxycorticosterone (DOC) and corticosterone in rats bearing transplanted mammotropic tumors (MtT/F4) were measured simultaneously by means of a new competitive protein-binding method. Increased plasma levels of DOC (25-fold), as well as progesterone (6-fold) and corticosterone (3.5-fold) in rats bearing the tumors were observed when compared to control rats. Plasma aldosterone was decreased. The adrenal glands in tumor-bearing rats being 8-fold larger than in control rats, the ratio of the steroid concentration in plasma per milligram adrenal gland weight showed an increased DOC production, while no change in progesterone and decreased corticosterone production was observed. These findings suggest that the increased DOC production plays a role in the pathogenesis of hypertension in these rats and that the disproportionate change in steroid production is due to reduced llβ-hydroxylating activity in the adrenal cortex possibly related to the excessive am...
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