Abstract
Background:Soluble P-selectin (sP-selectin) is associated with risk factors for cardiovascular disease (CVD) but this association has not been evaluated in patients with schizophrenia. This study primarily evaluated the association of sP-selectin with plasma lipids and nitrite (NO2−) respectively in overweight/obese adults with schizophrenia.Methods:One-hundred and six patients with schizophrenia (mean age 32.9 years; 71.60% male) were recruited from a psychiatric hospital. Participants completed a structured interview and provided a fasting blood sample. Body mass index (BMI) was used to divide the sample into normal weight and overweight/obese groups. Pearson’s and partial correlation coefficients (controlling for age, sex, race, education, and inflammation) were calculated to examine the association of sP-selectin with plasma lipids, and NO2− in the overweight/obese patients (primary analysis), as well as in the normal weight patients and the total sample (exploratory analyses).Results:After controlling for potential confounders, sP-selectin positively correlated with triglycerides (r = 0.38, p = 0.01) and NO2− (r = 0.40, p < 0.01) in the overweight/obese group only.Conclusions:Future longitudinal studies should evaluate the utility of sP-selectin as a biomarker of CVD in overweight/obese adults with schizophrenia (for example, by relating sP-selectin to incidence of cardiovascular events).
Highlights
Patients with schizophrenia have increased rates of cardiovascular disease (CVD)-related morbidity and mortality, resulting in approximately 11-20 years decreased lifespan and up to 2.5 greater odds of dying in comparison to adults without a psychiatric illness [1, 2]
We previously found that in overweight/obese patients with schizophrenia, peripheral inflammation and triglycerides (TG) were elevated, while high-density lipoprotein-cholesterol (HDL-C) level was low [19]
Since dyslipidemia and nitric oxide (NO) are both involved in the pathophysiology of atherosclerosis, we aimed to evaluate the association of sP-selectin with plasma lipids and NO2- in the same overweight/obese patients with schizophrenia
Summary
Patients with schizophrenia have increased rates of cardiovascular disease (CVD)-related morbidity and mortality, resulting in approximately 11-20 years decreased lifespan and up to 2.5 greater odds of dying in comparison to adults without a psychiatric illness [1, 2]. Overweight/obesity is an important factor contributing to CVD in patients with schizophrenia [3]. P-selectin is an important factor for atherogenesis as highlighted by the fact that P-selectin knockout mice exhibit negligible atherosclerosis [8] while mice genetically modified to overproduce soluble P-selectin (sP-selectin) exhibit. Soluble P-selectin (sP-selectin) is associated with risk factors for cardiovascular disease (CVD) but this association has not been evaluated in patients with schizophrenia. This study primarily evaluated the association of sP-selectin with plasma lipids and nitrite (NO2-) respectively in overweight/obese adults with schizophrenia
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