Abstract
The aim of this split mouth, double blinded, randomized clinical trial was to evaluate the clinical efficacy of use of Plasma rich in growth factors (PRGF) as an adjunct to scaling and root planing (SRP) in the treatment of periodontal pockets. Twenty six patients (15 males, 11 females) diagnosed with generalized periodontitis with Pocket Depth > 5mm and plaque index score < 1.5, were randomly allocated by using computer generated random sequence, into two groups, one treated with intra-pocket application of PRGF adjunct to SRP and other with SRP alone. The clinical outcomes like pocket depth (PD), relative attachment level (RAL) and sulcus bleeding index (SBI) were assessed at baseline, 3 months and 6 months. Twenty two patients (44 sites) were analyzed at the end of 6 month follow-up, using SPSS 20.0v software. There was a significant statistical difference observed between both the groups favouring SRP +PRGF group in terms of PD (p = 0.007) and RAL (p = 0.021) at the end of 6 month follow-up. Also there was a statistical significant difference (< 0.001) at all time points compared to baseline, for all parameters in intra-group comparison. Moreover, the sites with PD>4mm necessitating further treatment after 6-month follow-up were significantly lesser for SRP+PRGF group. The use of PRGF technology in non-surgical periodontal therapy, by single intra-pocket application in to periodontal pockets as an adjunct to SRP, in chronic periodontitis patients, was found to be effective in reduction of pocket depth and gain in clinical attachment level.
Highlights
Periodontal disease is an inflammatory destruction of the supporting structures of teeth caused by pathogenic bacteria leading to loss of epithelial attachment.[1]
Patients presenting with two contra-lateral sites with probing depth ≥ 5 mm associated with premolar and molar teeth with no furcation involvement, full mouth plaque index score < 1.5 22 having no systemic disease or debilitating conditions, or use of any medications which could affect the outcome of periodontal therapy, with no history of any periodontal
Twenty-six patients with two contra-lateral pockets > 5mm were selected for the study
Summary
Periodontal disease is an inflammatory destruction of the supporting structures of teeth caused by pathogenic bacteria leading to loss of epithelial attachment.[1]. The primary goal of periodontal therapy is to eliminate microbial plaque and calculus and allow the periodontal tissues to heal.[2] Proper debridement of plaque and calculus from the periodontal pockets can be achieved by the use of non-surgical approaches such as scaling and root planing (SRP). Once this is accomplished, surgical part of the treatment could be initiated when indicated.[3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
