Plasma rich in growth factors had limited effect on early bone formation in extraction sockets

Abstract

AbstractAimTo address the criticisms raised by Anitua et al. (European Journal of Oral Implantology, 6, 2013, 9–11) to the article “Plasma Rich in Growth Factors (PRGF) in Human Post‐Extraction Sockets: an Histological and Histomorphometric Study.”, recently published by Farina and colleagues (Clinical Oral Implants Research 2012; doi: 10.1111/clr.12033).MethodsAll the methodological aspects criticized in the letter by Anitua et al. were thoroughly reconsidered and discussed in a structured short communication. When indicated, pertinent, additional material was included to reinforce our considerations.ResultsAs most clinical studies in implant dentistry, including previous studies evaluating the efficacy/effectiveness of PRGF, the study by Farina et al. has some limitations. However, it is currently the only published controlled trial using quantitative parameters related to PRGF‐induced early bone formation.ConclusionsDespite all limitations, the results of the study by Farina et al., which were based on different quantitative parameters (micro‐CT scan, immunohistochemical markers of wound healing and bone deposition), indicated a limited effect of PRGF on early bone formation in extraction sockets.