Abstract
The relationship between C-reactive protein (CRP) levels and plasma antioxidants has been established in adults. However, the association has been rarely investigated in healthy children. Thus, we examined the cross-sectional association of high-sensitivity CRP (hs-CRP) levels with fat-soluble plasma antioxidant concentrations in a cohort of healthy prepubertal children. We determined hs-CRP levels in 543 healthy six–eight-year-old children using a high-sensitivity CRP enzyme-linked immuno sorbent assay (ELISA) kit. The plasma concentrations of lipids, apolipoproteins and lipid-soluble antioxidants (α-tocopherol, γ-tocopherol, lycopene, α-carotene, β-carotene and retinol) were determined using standardized methods. Pearson correlation analysis showed significant correlations between plasma hs-CRP and α-carotene and retinol concentrations. After adjusting by sex, body mass index (BMI) and lipid levels, only the association with retinol remains significant, with children in the highest hs-CRP tertile group (hs-CRP ≥ 0.60 mg/dL) showing significantly lower levels of retinol than those from the tertiles 1 and 2. A stepwise linear regression selected retinol, BMI, apo A-I and sex as predictors of hs-CRP levels, in a model explaining 19.2% of the variability of hs-CRP. In conclusion, in healthy prepubertal children, after adjusting by sex, BMI and lipid levels, hs-CRP concentrations were highly associated with plasma retinol, which is transported in blood bound to retinol-binding protein but were not associated with the lipoprotein-bound antioxidants.
Highlights
C-reactive protein (CRP) is an acute-phase inflammatory protein synthesized in the liver through the stimulation of interleukin-6 that has been extensively studied as a marker of the subclinical inflammation associated with obesity, metabolic syndrome, diabetes and cardiovascular disease [1].It is known that oxidative stress has pro-inflammatory effects, and an important role in this association has been attributed to CRP [2]
We examined the association of high-sensitivity CRP (hs-CRP) levels with plasma antioxidant (α-tocopherol, γ-tocopherol, lycopene, α-carotene, β-carotene and retinol) concentrations in a cohort of healthy prepubertal children in Spain
This study describes the relationship between the plasma concentration of fat-soluble antioxidants and hs-CRP levels in a healthy cohort of prepubertal children where the effect of sex hormones, alcohol consumption and the smoking habit can be avoided
Summary
C-reactive protein (CRP) is an acute-phase inflammatory protein synthesized in the liver through the stimulation of interleukin-6 that has been extensively studied as a marker of the subclinical inflammation associated with obesity, metabolic syndrome, diabetes and cardiovascular disease [1].It is known that oxidative stress has pro-inflammatory effects, and an important role in this association has been attributed to CRP [2]. C-reactive protein (CRP) is an acute-phase inflammatory protein synthesized in the liver through the stimulation of interleukin-6 that has been extensively studied as a marker of the subclinical inflammation associated with obesity, metabolic syndrome, diabetes and cardiovascular disease [1]. Plasma antioxidants seem to decline during the “acute-phase response” in the inflammatory process that is associated with the increase of inflammatory markers, such as CRP [3]. The association of these biomarkers with reduced antioxidant levels in low-grade inflammation remains under study. Nutrients 2018, 10, 1257 trials analyzing the effect of vitamin E supplementation suggests that supplementation with either α-tocopherol or γ-tocopherol reduces blood CRP concentrations [4]. Schwab et al [5] suggested that this association was found only with vitamin E in combination with the intake of other antioxidants
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
