Abstract
AIM: To explore the clinical efficacy and side effects of plasma replacement therapy for severe viral hepatitis. METHODS: Forty-two cases of severe hepatitis patients were enrolled who were not responsive to medication therapy. Clinical symptoms and signs, liver and kidney function, electrolytes and coagulation of patients were observed for the first three times before and after treatment. RESULTS: Clinical symptoms, signs and liver function improved significantly after treatment with plasma replacement. Compared with pretreatment, ALB and CHE after treatment increased significantly, but ALT, AST, ALP, GGT, TBA and TBIL decreased significantly. There was a significance difference in ammonia level between the third time and pre-treatment (49.00 ± 12.03 vs 69.96 ± 34.87, P < 0.05). There were no significant differences in blood electrolyte change, coagulation and kidney function between post-treatment and pre-treatment. CONCLUSION: Plasma replacement therapy remove toxins of hepatitis patients, supply biologically active substances in patients with liver dysfunction, improve the local environment and liver function, prevent complications, decrease mortality and improve the prognosis.
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