Abstract
In previous papers we have seen that in clinical hypertension plasma renin concentration is inversely related to plasma sodium, and we have discussed this association from the aspects of aetiology and complications (Brown et al., 1965a, 1965b, 1965c, 1966a). The present paper is concerned with renin in relation to treatment and prognosis. As we shall show, treat ment apparently causes changes in renin mainly when altera tions in sodium balance are involved. The clinical material studied and the methods used are as given previously (Brown et al., 1965b, 1965c, 1966a). The rela tionship between plasma renin concentration and other com ponents of the renin-angiotensin system, such as substrate con centration, angiotensin concentration, and renin activity, was also discussed in these earlier papers, and will not be considered further here.
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