Plasma Renin Activity (PRA) Predicts Diuretic Resistance in Acute Heart Failure Patients: An Ancillary Study of the Diuretic Optimization Strategies Evaluation in Acute Heart Failure (DOSE-AHF)

Abstract

Although diuretics are used as standard therapy in AHF, the response to diuretics is variable. Identification of patients at increased risk for diuretic resistance upon admission for AHF may allow earlier use of more aggressive diuretic regimens and/or adjuvant therapies. We hypothesized that increased PRA may reflect sodium avidity and thus predict diuretic resistance in AHF patients.