Abstract
Sepsis is associated with significant mortality. Early diagnosis and prognosis of patients with sepsis is still a difficult clinical challenge. In this study, the ability of plasma PTX3 (pentraxin 3), MCP1 (monocyte chemoattractant protein 1) and Ang (angiopoietin)1/2 was investigated to evaluate the severity of sepsis. Blood samples were obtained from 43 patients with sepsis. A total of 33 post‐surgery patients with infections and 25 healthy individuals served as controls. The results showed that plasma PTX3, MCP1 and Ang2 significantly increased in patients on the first day of septic shock onset, while sepsis patients had significantly higher Ang2 level, compared with controls. Furthermore, PTX3, MCP1 and Ang2 had high AUROC values in patients with septic shock on the first day of sepsis onset. The findings suggest that PTX3, MCP1 and Ang2 maybe early predictors to evaluate the severity of sepsis and septic shock with the latest Sepsis 3.0 definitions.
Highlights
Sepsis is a serious disorder of the body against bacterial or other pathogens and induces multiple organ dysfunction
The present study evaluated the diagnostic values of Monocyte chemoattractant protein 1 (MCP1), PTX3, Ang[1] and Ang[2] in patients with sepsis and septic shock according to the latest Sepsis 3.0 definitions
The results showed that MCP1, PTX3 and Ang[2] had higher levels in sepsis patients, especially in those with septic shock, compared with controls
Summary
Shanghai Science and Technology Innovation Fund, Grant/Award Number: 184119500900; Key Discipline Construction of Shanghai Municipal Commission of Health and Family Planning, Grant/Award Number: 2016ZB0206; National Natural Science Foundation of China, Grant/Award Number: 81772040; Project of Shanghai Municipal Commission of Health and Family Planning, Grant/Award Number: ZY(2018‐2020)‐FWTX‐1108
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