Abstract
BackgroundLeft ventricular hypertrophy (LVH) has been associated with oxidative stress, although not with the protein thiolation index (PTI). This study explored the potential use of PTI as a biomarker of oxidative stress in patients with LVH.MethodsWe recruited 70 consecutive patients (n = 35 LVH and n = 35 non-LVH) based on an echocardiography study in our institution (left ventricular mass indexed to body surface area). Plasma levels of both S-thiolated protein and total thiols were measured as biomarkers of oxidative stress by spectrophotometry, and PTI was calculated as the molar ratio between S-thiolated proteins and the total thiol concentration.ResultsValues for plasma S-thiolated proteins were higher in patients with LVH than in the control group (P = 0.01). There were no differences in total thiols between the LVH group and the control group. Finally, PTI was higher in patients with LVH than in the control group (P = 0.001). The area under the ROC curve was 0.75 (95% CI, 0.63–0.86; P<0.001), sensitivity was 70.6%, and specificity was 68.6%, thus suggesting that PTI could be used to screen for LVH. A multivariable logistic regression model showed a positive association (P = 0.02) between PTI and LVH (OR = 1.24 [95% CI, 1.03–1.49]) independently of gender (OR = 3.39 [95% CI, 0.60–18.91]), age (OR = 1.03 [95% CI, 0.96–1.10]), smoking (OR = 5.15 [95% CI, 0.51–51.44]), glucose (OR = 0.99 [95% CI, 0.97–1.01]), systolic arterial pressure (OR = 1.10 [CI 1.03–1.17]), diastolic arterial pressure (OR = 0.94 [CI 0.87–1.02]), dyslipidemia (OR = 1.46 [95% CI, 0.25–8.55]), estimated glomerular filtration rate (OR = 0.98 [95% CI, 0.96–1.01]), body mass index (OR = 1.03 [95% CI, 0.90–1.10]), and valvular and/or coronary disease (OR = 5.27 [95% CI, 1.02–27.21]).ConclusionsThe present study suggests that PTI could be a new biomarker of oxidative stress in patients with LVH.
Highlights
Left ventricular hypertrophy (LVH) is a mechanism by which the heart adapts to different types of stress [1]
This study explored the potential use of protein thiolation index (PTI) as a biomarker of oxidative stress in patients with LVH
PTI was higher in patients with LVH than in the control group (P = 0.001)
Summary
Left ventricular hypertrophy (LVH) is a mechanism by which the heart adapts to different types of stress [1]. Certain pharmacological treatments produce regression of LVH and decrease the incidence of cardiovascular adverse events and mortality in affected patients [6,7,8,9,10,11]. 21 studies show that the accuracy of electrocardiographic indexes in the diagnosis of LVH is unsatisfactory [13]. The cost-effectiveness of routine echocardiography for diagnosis of LVH has been debated [17]. Left ventricular hypertrophy (LVH) has been associated with oxidative stress, not with the protein thiolation index (PTI).
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