Abstract
Background: Amadori-modified glycated plasma proteins play an important role in diabetic microangiopathy. Many of the pathogenic changes that occur in diabetic nephropathy (DN) may be induced by non-enzymatic glycation (NEG). Objective: The aim of this study was to determine prevalence of DN and non-enzymatic glycation levels in diabetic population. Methodology: One hundred patients with type 2 diabetes and forty healthy control subjects were recruited after consent. Case participants were further divided into two groups as type 2 diabetics with nephropathy (n = 22) and type 2 diabetics without nephropathy (n = 78). Non-fasting plasma glucose (Trinder GOD-PAP method), total plasma proteins (biuret method), Erythrocyte sedimentation rate (Westergren's method), HbA1c (glycohemoglobin spectrophotometry A1c Kit) and non-enzymatic glycation (TBA colorimetric technique) were assayed. Results: Diabetic patients with nephropathy had higher ESR (55.33 ± 24.68 mm/1st hour vs. 46.88 ± 23.95 mm/1st hour vs.12.73 ± 2.34 mm/1st hour), total proteins (15.71 ± 4 g/dL vs.14.01 ± 4 g/dL vs 6.18 ± 1.16 g/dL) and non-enzymatic glycation (1.73 ± 0.48 mol./mol. vs.1.47 ± 0.58 mol./mol. vs. 0.48 ± 0.18 mol./mol.) measurements as compared to those without any similar renal complications and controls. Appreciable correlation existed between hyperglycemia and non-enzymatic glycation. Conclusion: Although the clinical consequences of NEG of circulating proteins remain ambiguous. In diabetic patients, however, extensively glycated species could exhibit significant alterations in function. Present study suggests DN as a frequently prevalent secondary complication of diabetes with a potential link with elevated NEG and glycemic control. Key words: Diabetic microangiopathy; nephropathy; glycated serum proteins.DOI: 10.3329/bjms.v9i2.5654Bangladesh Journal of Medical Science Vol.09 No.2 Apr 2010 pp.68-75
Highlights
Diabetic nephropathy (DN) is a major Nephropathy remains a significant cause of cause of morbidity and is associated with morbidity and mortality in the diabetic increased cardiovascular mortality in type population and is the leading cause of end
Pathological changes in the kidney, the As a result of the diabetic milieu, increased clinical course, and the overall risk to generation of reactive oxygen species develop nephropathy are quite similar in thought to play a key role in the both types of diabetes.[1]
One quarter of all patients requiring renal transplants, are diabetics.[3] advanced glycation end products (RAGE), which is central to the advanced glycation pathway, may mediate renal structural and
Summary
Diabetic nephropathy (DN) is a major Nephropathy remains a significant cause of cause of morbidity and is associated with morbidity and mortality in the diabetic increased cardiovascular mortality in type population and is the leading cause of end-2 diabetes mellitus. Many of the pathogenic changes that occur in diabetic nephropathy (DN) may be induced by non-enzymatic glycation (NEG). Objective: The aim of this study was to determine prevalence of DN and non-enzymatic glycation levels in diabetic population. Results: Diabetic patients with nephropathy had higher ESR (55.33 ± 24.68 mm/1st hour vs 46.88 ± 23.95 mm/1st hour vs.12.73 ± 2.34 mm/1st hour), total proteins (15.71 ± 4 g/dL vs.14.01 ± 4 g/dL vs 6.18 ± 1.16 g/dL) and non-enzymatic glycation Vs 0.48 ± 0.18 mol./mol.) measurements as compared to those without any similar renal complications and controls. Present study suggests DN as a frequently prevalent secondary complication of diabetes with a potential link with elevated NEG and glycemic control
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