Plasma Prolidase Activity and Oxidative Stress in Patients with Parkinson's Disease.

Akhilesh Kumar Verma,Shalabh Srivastava,Tej Bali Singh,Vivek Sharma,Janak Raj,Ragini Srivastava

doi:10.1155/2015/598028

Akhilesh Kumar Verma, Shalabh Srivastava + Show 4 more

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https://doi.org/10.1155/2015/598028

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Abstract

Prolidase deficiency has been related to mental retardation and oxidative stress. The study aimed to observe plasma prolidase activity (PPA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in patients with Parkinson's disease (PD). 240 subjects with PD and 150 healthy volunteers were considered as cases and controls, respectively. PPA, TOS, TAS, and OSI were measured spectrophotometrically. PPA and TAS in cases were more significantly decreased than controls (P < 0.01), while TOS and OSI were significantly increased (P < 0.001). In cases, nonsignificant, positive correlation was observed between PPA and TOS and OSI while significant, negative correlation was observed between PPA and TAS (P = 0.047). PPA in cases was nonsignificantly decreased with increased duration of PD (P = 0.747) while TAS was significantly decreased (P < 0.001) and TOS and OSI were significantly increased (P < 0.001). It was observed that higher age groups had decreased PPA, and TAS and increased TOS and OSI compared to lower age groups in cases. In summary, patients with PD have decreased PPA and increased oxidative stress compared to healthy volunteers. PPA was associated with oxidative stress markers in patients with PD. Decreased PPA and TAS and increased TOS and OSI were associated with progression of disease and higher age.

Highlights

Parkinson’s disease (PD) is the second most common neurodegenerative disorder that mostly affects old people [1]
A report of Mantle et al suggested that proline endopeptidase activity decreases in brain tissue of patients with Alzheimer’s disease, Parkinson’s disease, and Lewy body dementia compared to healthy individuals [12]
For evaluating plasma proline exopeptidase activity in patients with PD, we aimed to investigate the correlation between plasma prolidase activity and oxidative stress markers in patients with PD

Summary

Introduction

Parkinson’s disease (PD) is the second most common neurodegenerative disorder that mostly affects old people [1]. Increased oxidative stress and inflammatory mediators such as reactive oxygen species, reactive nitrogen species, proinflammatory cytokines, and complement component have been reported in substantia nigra as well as in cerebrospinal fluid of patients with PD [3]. Prolidase activity has been associated with oxidative stress in different diseases [7,8,9,10,11]. A report of Mantle et al suggested that proline endopeptidase activity decreases in brain tissue of patients with Alzheimer’s disease, Parkinson’s disease, and Lewy body dementia compared to healthy individuals [12]. In the case of Alzheimer’s disease, brain tissue proline endopeptidase activity decreased [12], while serum prolidase (proline exopeptidase) activity was increased with increase in oxidative stress [7].

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