Abstract
Prostaglandin F 2α (PGF 2α) tablet was inserted into the vagina of three female volunteers during the luteal phase of their cycle, and of three early pregnant women of 6 to 10th week gestation. No effect was observed on peripheral plasma progesterone level in the cases of induction of menstruation, however, vaginal bleeding occurred in all three cases. For the induction of abortion, plasma progesterone levels decreased slightly in a few hour after administration of PGF 2α. Complete abortion in a case and vaginal bleeding in two cases also occurred. The data obtained in this study indicate that the vaginal administration of PGF 2α does not exhibit a luteolytic effect and exerts a stimulating effect on the myometrium.
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