Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters.

Yuanyuan Luo,Huacong Deng,Hang Wang,Hua Qu,Dan Liu,Jing Wu,Huili Wei,Yang Duan

doi:10.1155/2016/6423637

Abstract

The purpose of this study is to examine the relations among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation in Chinese patients with obesity (OB), and type 2 diabetes mellitus (T2DM). Plasma periostin levels in the T2DM group were significantly higher than the NGT group (P < 0.01). Patients with both OB and T2DM had the highest periostin levels. Correlation analysis showed that plasma periostin levels were positively correlated with weight, waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR), fasting plasma glucose (FPG), 2 h postchallenge plasma glucose (2 h PG), glycated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), TNF-α, and IL-6 (P < 0.05 or 0.001) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) (P < 0.001). Multiple linear regression analysis showed that TG, TNF-α, and HOMA-IR were independent related factors in influencing the levels of plasma periostin (P < 0.001). These results suggested that Chinese patients with obesity and T2DM had significantly higher plasma periostin levels. Plasma periostin levels were strongly associated with plasma TG, chronic inflammation, and insulin resistance.

Highlights

Dyslipidemia, characterized by elevated triglyceride (TG), low levels of high-density lipoprotein cholesterol (HDL-C), and the abundance of low-density lipoprotein cholesterol (LDL-C) particles, is quite common in patients with type 2 diabetes (T2DM) [1]
Studies have shown that the liver can produce several secreted proteins such as fibroblast growth factor 21 (FGF21) [4], α2-HS-glycoprotein (Fetuin-A) [5], and pancreatic-derived factor (PANDER) [6] to help regulate hepatic and systemic glucose and lipid metabolism
Between the normal glucose tolerance (NGT) group and the type 2 diabetes mellitus (T2DM) group, there were no significant differences in age, systolic blood pressure (SBP), height, weight, and body mass index (BMI)

Summary

Introduction

Dyslipidemia, characterized by elevated triglyceride (TG), low levels of high-density lipoprotein cholesterol (HDL-C), and the abundance of low-density lipoprotein cholesterol (LDL-C) particles, is quite common in patients with type 2 diabetes (T2DM) [1]. While higher levels of TG in both the fasting state and the nonfasting state are considered the dominant lipid abnormality in insulin resistance and play a pivotal role in determining the characteristic lipid profiles of diabetic dyslipidemia [2], the efforts to understand the pathogenesis of T2DM are increasingly focusing on the disordered lipid metabolism. It is known that both lipid and glucose are involved in energy metabolism and can be regulated by the liver, which plays a pivotal role in maintaining energy homeostasis during fed-fasting transitions. Studies have shown that the liver can produce several secreted proteins such as fibroblast growth factor 21 (FGF21) [4], α2-HS-glycoprotein (Fetuin-A) [5], and pancreatic-derived factor (PANDER) [6] to help regulate hepatic and systemic glucose and lipid metabolism. The liver may act as a middle coordinator that bridges the hypertriglyceridemia and insulin resistance [7]

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