Abstract
Aim: Proprotein convertase subtilisin/kexin 9 (PCSK9), a protein regulating the number of cell-surface low-density lipoprotein (LDL) receptors (LDL-R), circulates partially associated to LDL, high-density lipoproteins (HDL) and lipoprotein (a). How this interaction alters PCSK9 plasma levels is still unclear. In the present study, we investigated whether a condition of familial hypoalphalipoproteinemia (FHA), due to genetic mutations in LCAT, ABCA1 or APOAI genes, could alter PCSK9 levels and distribution among different lipoproteins.
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