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Abstract
A gas-liquid chromatographic method for determining the concentration of amino acids in biological fluids was used to determine the concentration of para-chlorophenylalanine (pCPA) in plasma and urine. After its removal from plasma or urine by an ion exchange resin, pCPA was converted to a volatile n-butyl- N-trifluoroacetyl ester. Using this method we evaluated the plasma concentration and the urinary excretion of pCPA in six patients with the carcinoid syndrome treated with pCPA for up to 18 months. We confirmed the prolonged plasma half-life (13 hr) of pCPA. The urine excretion of unchanged pCPA was approximately 10% of the administered dose, either in an acute-loading situation or with chronic-maintenance administration. The symptomatic response of the diarrhea in the patient with the carcinoid syndrome was more consistently associated with the suppression of urinary 5-hydroxyindoleacetic acid excretion than either the pCPA plasma concentration or the serum serotonin level.
Published Version
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