Plasma Omentin-1 Levels Are Similar in Nondiabetic Metabolic Syndrome Patients and Healthy Subjects

Abstract

Background: Omentin-1 which is mainly produced by omental adipose tissue and associated with insulin dependent glucose uptake is less in obese patients than lean subjects. The aims of this study were; first, to compare plasma omentin-1 levels between nondiabetic metabolic syndrome patients and healthy controls and second, to investigate the association of plasma omentin-1 with metabolic parameters. Methods: According to International Diabetes Federation (IDF) criteria, 50 nondiabetic metabolic syndrome patients (23 male, 27 female) and 30 healthy control subjects (9 male, 21 female) were recruited in this study. After 12 hour-fasting, plasma omentin-1 levels were measured by enzyme-linked immunosorbent assay (ELISA) in venous blood samples. Results: There was no difference in plasma omentin-1 levels between metabolic syndrome patients and control subjects (90.53 ± 23.14 ng/mL, 87.83 ± 17.10 ng/mL respectively; p = 0.55). In all subjects, plasma omentin-1 was positively correlated with triglyceride and negatively correlated with HDL-C (r = 0.24, p = 0.029; r = -0.62, p = 0.019, respectively). Conclusion: The results of this study showed that although the plasma omentin-1 levels were correlated with high triglyceride and low HDL-C levels which are two of five metabolic syndrome’s parameters, the plasma omentin-1 levels are similar in metabolic syndrome patients and healthy controls. To investigate the tissue omentin-1 levels in the same groups may enlighten the topic. doi: 10.4021/jem46w