Plasma neutrophil gelatinase-associated lipocalin (NGAL) predicts renal function in hospitalized patients with heart failure

Abstract

Objective To explore the prognostic value of baseline plasma neutrophil gelatinase-associated the lipocalin(NGAL ) for worsening renal function in heart failure (HF). Methods We consecutively enrolled 396 patients hospitalized with HF and used chronic kidney disease epidemiology collaboration (CKD-EPI) formula to calculate estimated glomerular filtration rate (eGFR). All patients were divided into 2 groups: cardiorenal syndrome (CRS) group [eGFR<60 ml/(min·1.73 m2), n=97] and non-CRS group [eGFR ≥ 60 ml/(min·1.73 m2), n=299], indicators measuring the concentration of NGAL two groups of patients, N-terminal pro-brain natriuretic peptide (NT-proBNP), creatinine, serum urea nitrogen (BUN). Results In correlation analysis, r value between NGAL and NT-proBNP, creatine, BUN was 0.194, 0.527, and 0.433, respectively (P<0.01). The area under the receiver operating characteristic (ROC) curve of NGAL, NT-proBNP, BUN to evaluate worsening renal function was 0.863, 0.681, and 0.828, respectively (P<0.01). Conclusions Plasma NGAL was an independent worsening renal function predictor for hospitalized patients with heart failure. Key words: Lipocalins/ME; Gelatinases/ME; Heart failure/CO/ME; Kidney diseases/CO/ME