Plasma miRNAs and treatment failure among participants in the Treatment Options for Diabetes in Youth (TODAY) study

Abstract

<p dir="ltr">Objective</p><p dir="ltr">To identify plasma miRNAs related to treatment failure in youth with type 2 diabetes (T2D).</p><p dir="ltr">Research Design & Methods</p><p dir="ltr">We examined whether a panel of miRNAs could predict treatment failure in training/test datasets among participants in the Treatment Options for Diabetes in Youth (TODAY) Study (n=209). We also examined whether individual miRNAs were associated with treatment failure.</p><p dir="ltr">Results</p><p dir="ltr">Participants were 14.5 years old and 62% female. A panel of miRNAs did not predict treatment failure. However, for each doubling, miR-4306 was associated with a 12% decrease and miR-483-3p (p=0.040) was marginally associated with a 12% increase in failure (p=0.080) independent of sex, race/ethnicity, BMI, Tanner stage, HbA1c, maternal diabetes, oral disposition index, and treatment arm. The addition of both miRNAs improved model fit (log likelihood without miRNAs -360.3 vs. with -363.5, p=0.040).</p><p dir="ltr">Conclusions</p><p dir="ltr">miR-483-3p and miR-4306 may be associated with treatment failure in youth with T2D.</p>