Abstract
Since an acute dose of morphine caused changes in magnesium metabolism in rats, and since the ion is believed to be implicated in alcoholism and delirium tremens, tissue and urine magnesium was measured in rats treated chronically with morphine. The hypermagnesemia observed 1 hr after administration of the narcotic was the same at the beginning and at the end of a chronic morphine treatment. However, 8 hr after morphine injection, there was less magnesium in the plasma of morphinized rats; no change was observed in the concentrations of magnesium in muscle and bone. Chronic morphine treatment was associated with an increase in urine output and magnesium excretion. During morphine withdrawal, injection of magnesium had little effect on plasma concentration and urinary excretion of magnesium. These observations may be taken as evidence that magnesium does not play a major role in morphine tolerance and withdrawal phenomena.
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