Abstract
Background Long noncoding RNAs (lncRNAs) were recently shown to have potential in the diagnosis and prognosis for numerous cancers. lncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown. Materials and Methods We investigated the expression profile of plasma GAS8-AS1 in 97 patients with PTC and 39 patients with nodular goiter by quantitative real-time polymerase chain reaction. Results GAS8-AS1 expression in plasma was downregulated in patients with PTC in comparison with those in nodular goiters (P < 0.001). A low level of plasma GAS8-AS1 expression was correlated with lymph node metastasis (LNM) (P < 0.001). Multivariate analysis showed that a reduced GAS8-AS1 level in plasma was associated with LNM (P < 0.05). The area under the receiver operating characteristic curve for GAS8-AS1 was 0.746 in LNM prediction (P < 0.001). Conclusion The present study indicates that circulating GAS8-AS1 is a potential biomarker for PTC diagnosis and LNM prediction.
Highlights
Thyroid cancer is the most prevalent endocrine malignancy, and its incidence has increased dramatically over the last several decades [1]
Most patients with papillary thyroid cancer (PTC) have good prognosis, patients with certain clinicopathological features such as larger tumor size, lymph node metastasis (LNM), and advanced TNM stage are associated with a worse clinical outcome [4]
While the association between molecules in the thyroid and aggressive features has been investigated in several studies, potential circulating biomarkers are required to estimate the aggressiveness of cancer in patients with PTC
Summary
Thyroid cancer is the most prevalent endocrine malignancy, and its incidence has increased dramatically over the last several decades [1]. While the association between molecules in the thyroid (such as BRAF mutation [5, 6] and fibronectin-1 expression [7]) and aggressive features has been investigated in several studies, potential circulating biomarkers are required to estimate the aggressiveness of cancer in patients with PTC. LncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown. GAS8-AS1 expression in plasma was downregulated in patients with PTC in comparison with those in nodular goiters (P < 0 001). A low level of plasma GAS8-AS1 expression was correlated with lymph node metastasis (LNM) (P < 0 001). The present study indicates that circulating GAS8-AS1 is a potential biomarker for PTC diagnosis and LNM prediction
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