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Highlights

  • Optimisation of clinical response is only one goal of therapeutic drug monitoring and even when well-defined plasma levels are not estab lished for certain tricyclics, it still remains a useful tool in the management of depression

  • H. (1993) Sudden death and tricyclic antidepressants (TCAs): a rare adverse event linked to high TCA plasma levels

  • Scliirn:icTaol xiscyitmy pmtoamys.indHeeodweovcecr,ur 'CinNSthetoxaibcsietyn'ceandof delirium ore clinical symptoms and so plasma level determinations are of little use apart from to confirm that the antidepressant is the cause of the problem

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Summary

Introduction

Scliirn:icTaol xiscyitmy pmtoamys.indHeeodweovcecr,ur 'CinNSthetoxaibcsietyn'ceandof delirium ore clinical symptoms and so plasma level determinations are of little use apart from to confirm that the antidepressant is the cause of the problem. 1990) and 6% of patients have been reported to develop tricyclic-induced delirium on conven tional doses of 100-300 mg/day. At plasma levels greater than 1000 ng/l, most will show ECG changes {Spiker et cd, 1975). Optimisation of clinical response is only one goal of therapeutic drug monitoring and even when well-defined plasma levels are not estab lished for certain tricyclics, it still remains a useful tool in the management of depression.

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