Abstract
e15541 Background: Testicular germ-cell tumours (TGCTs) represent a model for the cure of cancer, nevertheless small proportion of patients experience tumor recurrence. Carbonic anhydrase 9 (CAIX) is a human transmembrane protein strongly associated with tumor hypoxia and cancer progression. In this study we investigated plasma CAIX in patients with TGCTs aimed to link the CAIX levels with patients`/tumor characteristics and plasma CAFs. Methods: In this ongoing translational study, plasma from 71 patients with TGCTs treated with first line of chemotherapy was collected. The concentrations of plasma CAIX were measured by enzyme-linked immunosorbent assay pretreatment (n = 71) and on day 22 (n = 65) of first cycle of chemotherapy. Plasma CAFs were measured using multiplex bead arrays (Human Group I and II cytokine panels and TGF beta by Bio-Plex 200 system). Results: Mean ± SEM plasma CAIX levels (pg/mL) pretreatment and on day 22 were 503.6 ± 116.8 and 478.5 ± 113.4, p = 0.2, respectively. We didn`t find ...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
