Abstract
Introduction:Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease.Observation:Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation.Results:Here we show that it is not the case in patients with suppressed viremia. Thus, IL-33 plays its alarmin role only during the early phase of the infection.
Highlights
Interleukin-33 (IL-33) is a cell damage-induced alarmin
We found a correlation between plasma sST2 concentrations and the following markers of immune activation: CD8+ T-cell count, percentage of HLA-DR+CD38+CD4+ T-cells, percentage of HLA-DR+CD38+CD8+ T-cells, percentage of PD-1 CD4+ T-cells, soluble CD14, soluble CD40L, interferon-γ, and plasma indoleamine-2,3-dioxygenase activity
Consistent with our previous findings [2] and with those of Secemsky et al [4], we found no difference in plasma sST2 concentrations between effectively-treated HIV-1-infected adults and age- and sex-matched healthy controls (Fig. 1a)
Summary
Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease. Observation: Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
