Abstract
We report the clearance of rat plasma kallikrein (RPK) by the perfused livers of normal rats and from others at 2 and 4 days after subcutaneous injection of turpentine oil. RPK removal from the perfusate follows a logarithmic curve (y = a+b lnx) and from this equation its half-life of removal can be calculated. RPK clearance rate followed the potential equation y = axb. Both the half-life of RPK removal and RPK clearance rates were similar in the 3 groups of perfused livers. We conclude that, at the initial concentration of RPK used (approximately 3 nM), its liver clearance is not affected during the acute-phase response to inflammation.
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