Abstract
In this study two plasma sources were used for an in vivo treatment of human stratum corneum. The sample preparation was realised with the Cyanoacrylat stripping method, whereby a few layers of corneocytes embedded in the lipid matrix were removed from the skin of healthy volunteers. For the plasma treatment, dielectric barrier discharges with pulse durations in the microsecond as well as in the nanosecond range were applied. A comparison of these sources with respect to their biologically active components including dissipated power, gas and electron temperature, irradiance in the ultraviolet range, ozone and nitric oxide concentration is presented. Furthermore, species generated during plasma treatment on the sample surface like hydrogen peroxide, nitride or nitrate were measured using reflectometry. In addition, safety aspects for both sources were evaluated. Resulting plasma induced changes in the sample composition were investigated through X-ray photoelectron spectroscopy. The main ingredients carbon, oxygen, and nitrogen in addition to minor concentrations of sulphur were considered. A significant influence of the pulse duration on plasma characteristics was shown. A more effective formation of reactive species as well as more intense UV emission for ns-plasma was observed. Based on the determined parameters, both plasma sources are suitable for therapeutic purpose. Furthermore, significant plasma induced changes in the stratum corneum composition were reported, including an increase in nitrogen and oxygen content.
Highlights
Plasma medicine is a young, rapidly growing field of research, which has a high innovation potential due to the development of the so-called “cold plasma”
Two plasma sources with comparable dissipated power, voltage amplitude and pulse repetition frequency, which only differ in the pulse duration and in the resulting discharge current, were applied
Several reactive oxygen species (ROS) and RNS were generated within the discharge volume
Summary
Plasma medicine is a young, rapidly growing field of research, which has a high innovation potential due to the development of the so-called “cold plasma”. It is possible to apply a plasma treatment to temperature sensitive materials like human skin, seeds and plants, or wood surfaces [1]-[5]. In dermatology, the treatment of various skin diseases such as atopic dermatitis, ichthyosis or pathological dry skin is a problem since these clinical pictures are considered incurable; only the relief of symptoms can be achieved by intensive care. In this field, plasma devices for skin treatment offer new possibilities
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