Abstract

The steady-state values in rats after a second 14-day period of daily subcutaneous administration of imipramine were the same as during the first period; liver demethylation activity rose for up to 3 days and then returned to normal. The imipramine-binding capacity of the serum, brain myelin, synaptosomes and mitochondria did not alter after repeated administration, but a decrease was found in the red blood cells. Stress (an electric current or immobilization) led to marked reduction of the plasma imipramine level, with a simultaneous increase in liver demethylase activity. Adrenalectomy caused a drop in demethylase activity; stress had no effect either on these values or on imipramine levels.

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