Abstract
Elevations of 2–4% in plasma osmolality were noted at the initiation of drinking following 4 days of fasting in rats. Paired animals food deprived for identical time periods but not drinking when blood sampled revealed ad lib levels of osmolality. Drinking initiation by 4 day food deprived rats following access to dry food was also accompanied by 2–4% elevations in plasma osmotic pressure. Substantial decreases in daily water consumption were observed during the 4 day food deprivation period accompanied by a mean plasma volume loss of 32% determined by T-1824 dye injection. Total blood volume loss was estimated to by 27%. Hematocrit was found to be the best estimator of plasma volume in starved rats. The elevations in plasma osmolality did not appear to be the result of uremia due to starvation induced protein catabolism. The data support the position that elevated plasma osmolality accompanies the initiation of drinking during extended fasting while return to ad lib set point osmolality accompanies cessation of drinking.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
