Abstract
We have studied the effects of secretin on human pancreatic polypeptide (hPP) secretion. Intravenous infusions of 0.1, 1.0, 1.5, and 2.0 clinical U secretin/kg BW given over 2 min at 30-min intervals caused rapid increases in hPP concentration t o peaks (mean ± SE) of 322 ± 37, 591 ±78, 720 ± 82, and 780 ± 103 pg/ml, respectively, from a basal level of 121 ± 58 pg/ml. The responses to these doses were not different when the secretin was given on different days, nor was there augmentation or diminution of response when four doses of 0.5 U/kg secretin were given sequentially at 30-min intervals. The hPP response to maximal stimulation (2 U/kg) with purified gastrointestinal hormone secretin was equivalent to that of crude Boots secretin. Vagotomy, which abolished the hPP and acid secretory response to hypoglycemia, failed to modify hPP responses to secretin, while atropine abolished it entirely in both healthy subjects and vagotomized patients, indicating a nonvagal cholinergic mechanism modulating the secr...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of clinical endocrinology and metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
