Abstract
Increased plasma homocystein (Hcy) is reported to be anindependent risk factor for neurodegenerative diseases[1]. Hcy may be involved in the potentiation of neuro-toxic and vasculopathic processes [2,3], leading to β Amy-loid (Aβ) and Tau protein accumulation in brains ofpatients with dementia. A positive association betweenplasma levels of Hcy and Aβ has been observed [4]. Theaim of the present study was to investigate whetherplasma Hcy in patients with Mild Cognitive Impairment(MCI) and Alzheimer's disease (AD) correlates with Tauprotein and Aβ in cerebrospinal fluid (CSF).
Highlights
Increased plasma homocystein (Hcy) is reported to be an independent risk factor for neurodegenerative diseases [1]
The aim of the present study was to investigate whether plasma Hcy in patients with Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) correlates with Tau protein and Aβ in cerebrospinal fluid (CSF)
Plasma Hcy, folate, vitamine B12, creatinine and CSF Tau protein, phosphorylated Tau protein (P-Tau), Aβ 1-42, Aβ 1-40 were assessed in patients with MCI (n=32) and AD (n=15)
Summary
Increased plasma homocystein (Hcy) is reported to be an independent risk factor for neurodegenerative diseases [1]. Address: Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Friedrich- Alexander Universitaet Erlangen- Nuernberg, Erlangen, Germany * Corresponding author from International Society on Brain and Behaviour: 3rd International Congress on Brain and Behaviour Thessaloniki, Greece.
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