Abstract
Introduction: Heme oxygenase-1 (HO-1) is a stress protein that is involved in protection of cardiac diaseases from diffrent noxious stimuli. Objective: We investigated whether plasma HO-1 is changed in cronic heart failure (CHF) patients and whether plasma HO-1measurements provide a peripheral biomarker of the disease. Methods: Plasma HO-1, were measured in 24 normal controls (NEC) and in 53 consecitive patients with CHF admitted to the Clinic of Cardiology over the period May 2010 - January, 2011. Systolic dysfunction was defined at left ventricle ejection fraction (LVEF) < 40%. Standardised protocol was used for colecting information on the investigated variables of interest. Plasma HO-1 and Brain natriuretic peptide (BNP) were measured with immunoassays. Depending on the distribution variables are reported with mean and median. Аssociations of the variables with HO-1 were investigated with linear regression analyses. Results: Plasma HO-1 concentrations (ng/ml) were significantly lower in CHF patients (median 2.58, range 0.5-7.3) compared with NEC (median 5.2 range 1.2-12.2) (p < 0.01). Circulating BNP levels were not significantly correlated with plasma HO-1 levels. There was a significant negative correlation between HO1 and serum total bilirubin (p<0.05). A negative weak correlations were also observed with functional class (p<0.05) and atrial fibrillation (p<0.05). Plasma levels of HO-1 showed a significant considerable positive correlation with left ventricle (LV) dimensions values. Independent predictive effects on HO-1 levels in multiple regression analysis (F=8.2, p<0.01) were explored for the values of the LV end-diastolic volume and artrial fibrillation. Conclusion: Plasma HO-1 are decreased in patients with CHF. Levels of HO-1 are independently correlated to the degree of cardiac enlargement. Further studies are needed on the concrete mechanisms of the deranged HO-1 regulation in CHF patients.
Highlights
Heme oxygenase-1 (HO-1) is a stress protein that is involved in protection of cardiac diaseases from diffrent noxious stimuli
If plasma HO-1 levels correlate with other components of the HO- 1 – carbon monoxide system and how it interrelate to the the neurohormonal response to heart damage and its strongest plasma biomarker for Chronic heart failure (CHF), such as brain natriuretic peptide (BNP) for instance [9,10,11]
We aimed to investigate whether plasma HO-1 are changed in CHF patients and whether plasma HO-1 measurements provide a peripheral biomarker of the disease
Summary
All patients underwent a detailed clinical examination and interview according to the standard protocol, to collect information on biologic and demographic data including age, gender, cardiovascular risk factors and blood pressure. The independent laboratory variables including parameters of the blood count, liver indices, creatinine, electrolytes and BNP were measured on a continuous measurement scale. Independent categorical variables include: age, gender, history of diabetes mellitus and arterial hypertension, etiology of CHF, atrial fibrillation (AF), pulmonary congestion and therapy. Reference categories for the set of the independent categorical variables were defined as age ≤ 65 years, male gender, non-diabetics, normotensives, non-ischemic etiology, sinus rhythm, negative data for pulmonary congestion, LVEF ≤ 40%, and no treatment with ACE/ARB blockers and β-blockers. Statistical analyses were done on the SPSS version 13.0 (SPSS Inc, Chicago, IL)
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