Plasma glucagon levels are associated with obesity, insulin resistance and metabolic syndrome in a general population cohort

Abstract

Rationale: Glucagon is a well- and long-recognized key regulator of hepatic glucose production playing a major role in plasma glucose control in both type 1 and type 2 diabetes. Experimental models have recently identified a role of glucagon in the regulation of energy balance and intermediate metabolism but potential associations between plasma glucagon, obesity and obesity-associated metabolic complications insulin resistance and metabolic syndrome in general population cohorts is largely unknown.