Abstract
ObjectivesGenistein is one of the main soy isoflavones in our daily diet. There were studies proving that high-dietary intake of genistein may relate to the low morbidity and mortality of prostate cancer (PCa) in the Asian population. Since there were few studies of plasma genistein level in the Chinese population, we performed this study to preliminarily evaluate the associations among plasma genistein, epidemiologic factors and PCa in a Chinese population.MethodsBetween 2012 and 2013, 100 men over the age of 40 underwent prostate biopsy for PCa at Huashan Hospital, Shanghai, China. Clinical information, epidemiologic information and blood samples were collected prior to biopsy for each patient. All patients underwent 10-core ultrasound-guided transperineal prostate biopsy, and the pathology results were collected after biopsy. We measured the plasma genistein concentration of the blood samples and analyzed the results along with the clinical and epidemiologic information.ResultsAmong the 100 patients, 46 (46.0 %) were diagnosed with PCa. The median plasma genistein concentration of non-PCa patients (728.6 ng/ml) was significantly higher than that of PCa patients (513.0 ng/ml) (P < 0.05). In the univariate analysis, we found that age and smoking history were related to PCa (P < 0.05). In the multivariate analysis, we found that age, smoking history and plasma genistein were related to PCa (P < 0.05). The age-adjusted odds ratio of PCa risk comparing plasma genistein level above median to that below median was 0.31 (95 % CI 0.13–0.71).ConclusionOur study suggested that high concentration of plasma genistein level may contribute to the low incidence of prostate cancer in Chinese population.
Highlights
Prostate cancer (PCa) is the second most common cancer and one of the leading causes of death in men population worldwide [1]
Our study suggested that high concentration of plasma genistein level may contribute to the low incidence of prostate cancer in Chinese population
The mean age and positive rate of smoking history were statistically higher in men diagnosed with PCa compared with the men without PCa (P < 0.05), whereas no significant difference in the positive rate of family history of cancer was observed between PCa and non-PCa groups (P > 0.05)
Summary
Prostate cancer (PCa) is the second most common cancer and one of the leading causes of death in men population worldwide [1]. Considering the possible reasons which caused the differences of incidence and morbility rate of PCa in Chinese and Western populations, preventive measures of PCa had been brought to the attention. The daily diet of Asian population including Chinese contains more soy products, and previous studies had shown that increased soy consumption was associated with a reduced risk of PCa [4,5,6,7]. It made soy food as one of the promising natural chemoprevention against PCa
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