Abstract

The turnover rate of plasma free fatty acids and of triglyceride in plasma very low density lipoprotein was studied in 15 obese subjects with a constant infusion of palmitic acid-1- 14C. The plasma FFA turnover rate was significantly correlated with the plasma FFA concentration. The FFA turnover rate was also significantly related to fat mass, to fat mass as a percentage of total body weight and especially to per cent desirable weight. Since it was not related to body weight, it is evident that the plasma FFA turnover rate is related to the degree of adiposity as distinct from total body weight. The plasma triglyceride levels were on the average higher than normal in these obese subjects. The turnover rate of triglyceride in very low density lipoproteins was significantly correlated with the triglyceride concentration, and showed that increased formation was a major factor in the development of the hypertriglyceridemia.

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