Abstract
Results of two types of metabolic studies are reported in depancreatized-hypophysectomized dogs maintained without hormonal replacement therapy. The response to a glucose load indicated the presence of severe diabetes, although the animals were not ketonuric and fasting plasma sugars fluctuated around 200 mg %. The response to a single growth hormone injection was that of an acute reduction of the concentration of plasma FFA. Since this occurred in the complete absence of the action of insulin, mechanisms other than insulin-dependent esterification were involved.
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