Abstract
Plasma free and sulfoconjugated catecholamines were measured 28 times in 19 healthy men who had been in a recumbent position for at least 60 min (mean ± s.e.m., pg/ml): free dopamine = 36 ± 8, sulfoconjugated dopamine = 5568 ± 544, free norepinephrine = 178 ± 11, sulfoconjugated norepinephrine = 645± 29, free epinephrine = 37 ± 4, and sulfoconjugated epinephrine = 451 ± 26. They were also measured during passive and active upright posture, during extracellular volume expansion induced by an intravenous infusion of sodium chloride, and during recumbency, as a control, to investigate whether the free sulfoconjugated relationship might have a physiological role. Data obtained do not support such a hypothesis, even during episodes of orthostatic hypotension. In the control group, there was a progressive decrease of sulfoconjugated catecholamines during recumbency, between 8 a.m. and 12 noon.
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