Abstract
Fluorescent oxidation products in plasma are stable with routine blood collection methods and reflect oxidation in food, animals, and in vitro. Whether plasma fluorescent oxidation products predict future coronary heart disease has not been established. Among US men without cardiovascular disease who provided blood specimens in 1994 in the Health Professionals Follow-up Study, the authors confirmed 266 incident nonfatal myocardial infarction or fatal coronary heart disease endpoints during 6 years of follow-up. Using a nested case-control design, they measured baseline levels of fluorescent oxidation products. Each case was matched with two controls according to age, smoking status, and time of blood draw. The relative risk of coronary heart disease between extreme quintiles was 1.83 (95% confidence interval: 1.07, 3.13; p for trend = 0.005) in the multivariate analysis controlling for other cardiovascular risk factors and traditional lipid markers. Further adjustment for C-reactive protein and glycated hemoglobin A(1c) did not materially attenuate this association. The multivariate-adjusted relative risk between extreme quintiles was 3.36 (95% confidence interval: 1.33, 8.48; p for trend = 0.005) when the analysis was restricted to men who had fasted for more than 10 hours before blood draw. The authors found that plasma fluorescent oxidation products significantly and independently predicted coronary heart disease incidence among men without previous cardiovascular events.
Highlights
The Harvard community has made this article openly available
To determine which cardiovascular risk factors were most strongly associated with fluorescent oxidation products, we calculated partial correlation coefficients adjusted for age
We found only modest associations of cardiovascular risk factors with fluorescent oxidation products
Summary
The Harvard community has made this article openly available. Please share how this access benefits you. Whether plasma fluorescent oxidation products predict future coronary heart disease has not been established. The relative risk of coronary heart disease between extreme quintiles was 1.83 (95% confidence interval: 1.07, 3.13; p for trend 1⁄4 0.005) in the multivariate analysis controlling for other cardiovascular risk factors and traditional lipid markers. The multivariate-adjusted relative risk between extreme quintiles was 3.36 (95% confidence interval: 1.33, 8.48; p for trend 1⁄4 0.005) when the analysis was restricted to men who had fasted for more than 10 hours before blood draw. The authors found that plasma fluorescent oxidation products significantly and independently predicted coronary heart disease incidence among men without previous cardiovascular events. Identification of a novel biochemical marker may enhance our understanding of the underlying pathophysiology of CHD Such a biomarker would be a useful clinical diagnostic tool to complement traditional diagnostic methods. A useful clinical predictor should be stable in samples collected by a simple method, relatively easy to measure in clinical and epidemiologic studies, and independently predictive of disease
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
