Abstract
SUMMARY Healthy volunteers received single doses of fentanyl O.5mg i.v. and the occurrence of respiratory depression was correlated with secondary peaks in the plasma concentrations of fentanyl. Plasma concentrations of fentanyl, tidal volume, minute volume, end-tidal Pco2 arterial blood-gas tensions, and response curves to carbon dioxide were determined during the total study period of 240 min. Secondary increases in the plasma concentrations of fentanyl occurred in four of the seven volunteers These four individuals showed marked depression of their carbon dioxide response curves and m two respiratory insufficiency was evident clinically.
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