Abstract
Endothelin-1 (ET-1) has been implicated in the pathogenesis of pulmonary vascular disease in patients with congenital heart disease. We studied the effect of pulmonary blood flow on plasma ET-1 concentrations. Systemic venous, pulmonary arterial, and pulmonary venous blood samples were obtained from 40 patients with atrial septal defect II ( n = 21), ventricular septal defect ( n = 10), persistent ductus arteriosus ( n = 6), and complete ( n = 2) and partial ( n = 1) atrioventricular canal at cardiac catheterization and analyzed by radioimmunoassay. Median age (range) was 5.2 years (8 months to 66 years), and the resistance ratio ( Rp Rs ) was 0.08 (0.03 to 0.67). Pulmonary vein to pulmonary artery ET-1 ratio in patients with “high flow” ( n = 26, Qp Qs ≥ 1.5 ; ET-1 ratio = 0.8) did not differ from those with “low flow” ( n = 14, Qp Qs < 1.5 ; ET-1 ratio = 1.0). We conclude that an increase in pulmonary blood flow alone does not result in an increase in plasma ET-1.
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