Abstract
ABSTRACT Plasma levels of deoxycorticosterone (DOC) were determined using a newly developed competitive-binding assay employing corticosteroid binding globulin. Normal men, women throughout the menstrual cycle, and women on oral contraceptives had DOC levels ranging from less than 5 to 10 ng/100 ml. Levels rose to over 100 ng/100 ml following an ACTH infusion and to over 1000 ng/100 ml following metyrapone. Neither a 10 mEq sodium diet nor an angiotensin II infusion caused a detectable increase in DOC. Seven patients with Cushing's syndrome due to excess pituitary ACTH had DOC levels ranging from less than 5 to 15 ng/100 ml, whereas 6 patients with Cushing's syndrome caused by ectopic ACTH production had levels in the range of 21 to 390 ng/100 ml. One patient with Cushing's syndrome due to an adrenal adenoma had undetectable DOC, whereas 4 of 6 patients with adrenal carcinoma had elevated DOC levels. Plasma DOC was elevated in patients with hypertension caused by either 11β-hydroxylase or 17-hydroxylase d...
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