Plasma cyclic AMP level in donors

Abstract

The concentration of cyclic adenosine-3′,5′-monophosphate (cyclic AMP) in the plasma of blood donors (10 regular, 28 first time) was investigated by the competitive protein binding method on the day before donation and shortly after the removal of 20 ml blood. Two types of responses of the donors to donation were established: with no change and with a change in the cyclic AMP level. In accordance with these responses the donors were conventionally divided into two subgroups-“stable” and “reactive.” The cyclic AMP level in the regular donors was higher than in the primary, and at the time of taking the blood it was increased still more, especially among the subjects of “reactive” type. The cyclic AMP concentration in first-time donors of reactive type was either lower or higher than the mean value on the day before donation, and at the time of bleeding it rose or fell respectively to the mean level.