Abstract
Plasma corticotropin (ACTH), growth hormone (GH) and cortisol responses to the iv injection of insulin at 9 am and 9pm were studied in normal subjects. ACTH and GH were determined by radioimmunoassay and cortisol by fluorometry. There were no significant differences between the absolute values of plasma ACTH, GH or cortisol concentrations observed following insulin hypoglycemia induced in the morning and in the evening, while the increment of plasma cortisol concentration from the basal level in the 9pm experiment was significantly higher than that of the 9 am experiment at 45, 60 and 90 min after insulin injection. The apparent discrepancy between the increment of cortisol concentration and ACTH concentration in plasma was discussed in relation to the normal response characteristics of the adrenal cortex to ACTH.
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