Abstract
SummaryA mammary quarter in each of 4 cows was infused with 0.5 mg E. coli endotoxin to determine its effect on plasma corticosteroids, circulating leukocytes and milk somatic cells. At 1.5 hr following endotoxin infusion, segmented neutrophils decreased 23%, and by 5 hr dropped 93%. A shift left in the differential circulating leukocyte count began at 2.5 hr and reached maximum proportions between 18-24 hr postendotoxin infusion. Circulating lymphocytes, monocytes and eosinophils were all depressed in response to endotoxin. Plasma corticosteroid concentrations increased (P < 0.01) 2 hr following endotoxin infusion, reached maximum concentrations at 4 hr, then returned to prein-fusion concentrations by 12 hr. The initial decrease in circulating lymphocytes at 2.5 hr was not attributed to the lytic effect of the plasma corticosteroids, since depressions in circulating lymphocytes occurred too soon (0.5 hr) after the increase in plasma corticosteroids. The high plasma corticosteroid concentration appeared t...
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