Plasma colloid osmotic pressure after blood volume repletion with Oxyglobin, hetastarch, or whole blood in pregnant sheep

Abstract

In preliminary measurements, Oxyglobin and hetastarch had colloidal osmotic pressures of 35 and 31 mm Hg, respectively, while ovine plasma (n = 17) had an osmotic pressure of 20 (16, 24) mm Hg, median (minimum, maximum). We hypothesized that Oxyglobin administration after hemorrhage would increase maternal plasma colloidal osmotic pressure (COP) more than hetastarch and that both would draw water from the fetus across an osmotic gradient.