Plasma citrulline in diagnosing of acute intestinal failure in patients with severe acute pancreatitis

Abstract

s / Pancreatology 13 (2013) S2–S98 S66 0% in patients with single-OF, 11.8% in patients with two-OF, 58.8% in patients with three-OF and 29.4% in patients with four-OF (z1⁄4-3.688, p<0.001). Conclusion: Elevation of IAP correlates with frequency of OF in patients with SAP. Mortality rate is higher in patients with multi-OF and higher IAP during SAP. PII-43 Abstract id: 91. Plasma citrulline in diagnosing of acute intestinal failure in patients with severe acute pancreatitis Oleksandr Rotar, Vasiliy Rotar. Emergency Care Hospital, Chernivtsi, Ukraine Introduction: Acute intestinal failure in patients with severe acute pancreatitis (SAP) is common and associated with a poor prognosis. However, a validated it’s definition is lacking. Plasma citrulline, an amino acid produced exclusively by enterocytes, might be a candidate. Aims: To assess ability of plasma citrulline in diagnosing acute intestinal failure in patients with SAP. Patients m 1–RL group with standard fluid resuscitation with RL 1000 ml solution, or 2-NS group witch standard fluid resuscitation with 1000 ml normal saline. All patients from both groups received additional 5% Glucose Solution and Multiple Electrolytes Solution. Results:We noted 63 (61.1%) patients with mild, 24 (23.3 %) moderate, 14 (13.6%) severe, and 2 (1.9%) critical AP. No significant difference in distribution of severity of AP between two groups was found. In 1-RL group we identified 21 (52.5%), 11 (27.5%), 6 (15.0%), 2 (5%) patients comparing to 42(66.7%), 13(20.6%), 8(12.7%) and 0 respectively in group 2NS; p1⁄40.230. No significant differences between 1-RL and 2-NS groups were found in terms of confirmed pancreatic necrosis (10 patients(25%) vs.12 patients(19 %), respectively); p1⁄40.637. There were no significant differences between 1-RL and 2-NS groups in mortality and duration of stay in the hospital. Conclusion: Our study did not confirm the favorable action of RL in the first days of AP. PII-45 Abstract id: 237. A comparative analysis of the selected scales for the assessment of prognosis in acute pancreatitis Dorota Koziel , Jaros A,aw Matykiewicz , Piotr Lewitowicz , Zuzanna Dro _ zd _ zak , Stanislaw Gluszek . 1 The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, Poland 2 Center for Evaluation and Analysis of Public Policies Jagiellonian University Cracow, Poland Introduction: The goal of the research conducted was to assess the usefulness of the selected prognostic scales for both the assessment of the severity and risk of death in patients suffered from acute pancreatitis (AP). Aims: Analysis of the selected scales for the prognosis in AP. Patients & methods: 1014 patients on 16 surgical wards of the Swietokrzyskie Province in Poland were admitted to hospital due to AP during one year. BISAP, Panc 3 score, Ranson scales were calculated on the basis ofthe data obtained during the first 24-hours of their stay on a ward. Results: Based on the modified Atlanta criteria, SAP was diagnosed in 6,9%, moderate pancreatitis in 12.0%, mild pancreatitis in 81.1% of the patients. The death rate due to AP was 3.9%, and in the severe form 52.9% and was significantly higher (p <0,05) than the death rate in the moderate form (no deaths) and the mild one (0.2%). Area under the receiver-operating curve (AUC) for BISAP, Ranson’ s, APACHE-II, and CTSI in predicting SAP are 0.61 (confidence interval (CI) 0.56 – 0.65), 0.53 (CI 0.49 – 0.58), 0.65 (CI 0.60 – 0.70), and 0.75 (CI 0.70 – 0.79), respectively. AUCs for BISAP, Ranson’ s, APACHE-II, and CTSI in predicting death are 0.71 (CI 0.62 – 0.80), 0.68 (CI 0.59 – 0.77), 0.73 (CI 0.62 – 0.83), and 0.49 (CI 0.37 – 0.59), respectively. Conclusion: The Balthazar grading system and CTSI demonstrated the highest accuracy among the CT scoring systems for predicting severity, but for predicting mortality was greatest predictive value APACHE II scale. PII-46 Abstract id: 131. Is bile microscopy reliable for diagnosis of microlithiasis in acute idiopathic pancreatitis? Jung Sik Choi , Hyoung-Chul Oh . 1 Division of Gastroenterology, Busan Paik Hospital, College of Medicine, Inje University, South Korea Division of Gastroenterology, Chung-Ang University College of Medicine, South Korea Introduction: Biliary microlithiasis has been suspected as one of the frequent etiologies of acute idiopathic pancreatitis. Polarized microscopic