Abstract
Abstract Background: The progression of atherosclerotic lesions and coronary artery disease is known to be accelerated by hypercholesterolemia. Objective: This study investigated at the effects of adding an extract of oyster mushroom fruiting bodies to rats with high and normal cholesterol levels on their biochemical and histological changes. This study was aimed to assess the effect of Pleurotus ostreatus extraction on hypercholesterolemia in albino rats and show the revelation of the relationship of these with some biochemical parameters. Materials and Methods: Three sets of ten albino rats each were formed from 6-week-old rats. To lower plasma total cholesterol, triglycerides, low-density lipoprotein (LDL), total lipid, phospholipids, and LDL/high-density lipoprotein, extracts of P. ostreatus fruiting bodies were fed to hypercholesterolemic rats. Results: In rats with high cholesterol, feeding oyster mushrooms drastically lowered body weight. The excretion of total lipids and cholesterol in feces was enhanced by feeding mushrooms. Conclusion: These findings imply that P. ostreatus food supplement improved health by altering hypercholesterolemic rats’ atherogenic lipid profiles.
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