Abstract
Objective To investigate plasma chemerin levels in ST elevation myocardial infarction (STEMI) patients and find out possible relationships between plasma chemerin levels and angiographic characteristics. Patients and Methods Ninety-seven consecutive patients who presented with STEMI and underwent primary percutaneous coronary intervention (PCI) with coronary stents were enrolled, and 30 age- and sex-matched patients with stable angina pectoris who underwent coronary angiography formed the control group. Angiographic characteristics of the patients including thrombolysis in myocardial infarction (TIMI) thrombus and Gensini scores were noted. Blood samples were taken to detect several biochemical markers including plasma chemerin levels at the admission to hospital. Results Serum chemerin and C-reactive protein (CRP) levels were significantly increased in patients with STEMI. Among STEMI patients, serum chemerin levels were significantly higher in patients with high thrombus burden (581.5 ± 173.7 versus 451.3 ± 101.2 mg/dL, p < 0.001). CRP levels and peak creatine kinase-MB (CK-MB) levels were higher, and left ventricular ejection fraction and post-PCI TIMI flow were lower in patients with high thrombus burden. After multivariate analysis, serum chemerin levels were also higher in patients with high thrombus grade (odds ratio: 1.009 (1.005–1.014), p < 0.001). Besides, serum chemerin levels were also found to be significantly correlated with CRP (r=0.47, p < 0.001) and peak CK-MB (r=0.376, p < 0.001) levels. Conclusions Results from our study have demonstrated for the first time that chemerin levels were higher in STEMI patients with greater thrombus burden and higher level of inflammation.
Highlights
Acute ST segment elevation myocardial infarction (STEMI) most commonly occurs when thrombus formation results in complete occlusion of a major epicardial coronary artery.e most serious form of acute coronary syndromes, STEMI is a life-threatening situation, and it must be diagnosed and treated promptly via coronary revascularization, usually by percutaneous coronary intervention or fibrinolytic therapy
When correlation analysis was performed, serum chemerin levels were found to be significantly correlated with C-reactive protein (CRP) levels (r 0.47, p < 0.001) and peak creatine kinase-MB (CK-MB) levels (r 0.376, p < 0.001). ere was no correlation between the serum chemerin levels and Gensini score (r 0.083, p 0.355)
Increased serum chemerin levels were associated with increased jeopardized myocardial area which was assessed by peak CK-MB levels and increased level of inflammation determined by CRP levels
Summary
To investigate plasma chemerin levels in ST elevation myocardial infarction (STEMI) patients and find out possible relationships between plasma chemerin levels and angiographic characteristics. Angiographic characteristics of the patients including thrombolysis in myocardial infarction (TIMI) thrombus and Gensini scores were noted. Serum chemerin and C-reactive protein (CRP) levels were significantly increased in patients with STEMI. Among STEMI patients, serum chemerin levels were significantly higher in patients with high thrombus burden (581.5 ± 173.7 versus 451.3 ± 101.2 mg/dL, p < 0.001). CRP levels and peak creatine kinase-MB (CK-MB) levels were higher, and left ventricular ejection fraction and post-PCI TIMI flow were lower in patients with high thrombus burden. Serum chemerin levels were higher in patients with high thrombus grade (odds ratio: 1.009 (1.005–1.014), p < 0.001). Results from our study have demonstrated for the first time that chemerin levels were higher in STEMI patients with greater thrombus burden and higher level of inflammation
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